Before we know what diseases will occur if the body becomes insulin resistant, let’s first understand this symptom.
Insulin resistance is a condition in which the body is less responsive to insulin than normal, causing the body to not absorb glucose into the cells, causing the body to produce more insulin than normal. This insulin resistance is often caused by genetics. Obesity, and lack of exercise. As for what diseases it causes, let’s see.
Diabetes due to insulin resistance
It usually occurs slowly. In the early stages, when insulin resistance occurs, the pancreas synthesizes and secretes more insulin. After several years, the pancreas becomes tired and the secretion of insulin decreases and becomes insufficient, causing blood sugar levels to rise and eventually diabetes. And if blood sugar levels cannot be controll to be in the normal range continuously,โปรโมชั่น ufabet it will result in severe diabetes.
Insulin resistance hypertension
When insulin levels are high, it stimulates the kidneys to reabsorb more sodium and makes the autonomic nervous system more sensitive. Blood flow through the capillaries in the muscles is reduce. Resulting in higher blood pressure.
Hyperlipidemia due to insulin resistance
Common lipid abnormalities in obese people are elevate levels. Of triglycerides or cholesterol in the blood, but lower levels of HDL-cholesterol (HDL-C). Because the liver takes free fatty acids and creates more fat molecules and releases them into the bloodstream. Insulin resistance also reduces the enzymes that break down fat, resulting in higher levels of fat in the blood. When blood cholesterol levels are high, it increases the risk of heart disease and clogged arteries.
Non-Alcoholic Fatty Liver Disease (NAFLD)
Because there is more free fatty acids being transported to the liver. They accumulate in the form of triglycerides, and also cause inflammation in liver cells and stimulate stellate cells, leading to liver fibrosis, cirrhosis, and eventually liver cancer.
Polycystic ovary syndrome (PCOs)
Found in women as a result of chronic anovulation, caused by hyperandrogenemia and insulin resistance with high blood insulin levels, excessive androgen levels, resulting in no ovulation and ovarian cysts. PCOS symptoms occur through 2 mechanisms. Lnsulin enhances the stimulation of Luteinizing Hormone, which stimulates Theca Cells in the ovaries. Resulting in increased production of testosterone, along with stimulating the expression of CYP17A 1, which is involved in the production of male hormones. It functions to convert androstenedione into testosterone. When there is a high level of insulin, it reduces the production of Sex Hormone Binding Globulin (SHBG) from the liver, which is a free and more active form of testosterone.